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Curr Opin Genet Dev. 2001 Oct;11(5):554-60.

Notch signaling in lymphocyte development.

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  • 1Department of Molecular and Cell Biology, University of California, Berkeley, 471 Life Science Addition, Berkeley, California 94720, USA.

Abstract

Signaling through Notch has been implicated in many cell-fate decisions during lymphocyte development. Recent studies have provided new clues--and raised new controversies--regarding the exact role that Notch signaling plays in the commitment of cells to the T-cell lineage. Progress has also been made in deducing the transcriptional program induced by Notch and the mechanism of oncogenic transformation by Notch in lymphocytes.

PMID:
11532398
[PubMed - indexed for MEDLINE]
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