Hematopoietic development: a balancing act

Curr Opin Genet Dev. 2001 Oct;11(5):513-9. doi: 10.1016/s0959-437x(00)00226-4.

Abstract

Over the past year, significant new insights have been gained in our understanding of the lineage determination of red blood cells. In particular, evidence has emerged demonstrating that cross-antagonism of lineage-specific transcription factors plays an important role in determining cell phenotype by actively repressing alternate lineage gene programs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / metabolism
  • Cell Differentiation
  • Cell Lineage*
  • DNA-Binding Proteins / metabolism
  • Erythroid-Specific DNA-Binding Factors
  • Hematopoiesis / genetics*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Nuclear Proteins / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism*

Substances

  • Carrier Proteins
  • DNA-Binding Proteins
  • Erythroid-Specific DNA-Binding Factors
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • ZFPM1 protein, human
  • proto-oncogene protein Spi-1