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Br J Dermatol. 2001 Sep;145(3):502-4.

Topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratoses.

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  • 1City of Dublin Skin and Cancer Hospital, Dublin 2, Ireland.


Scalp actinic keratoses (AKs) are common, particularly in elderly bald males. Cryotherapy and 5-fluorouracil are effective for localized AKs but are limited in extensive disease. Topical 5-aminolaevulinic acid photodynamic therapy (5-ALA PDT) is an alternative. We treated four patients with extensive scalp AKs with low light dose, low dose-rate topical 5-ALA PDT using a broad-spectrum visible light source. Three patients cleared and one showed significant improvement. Remission lasted 6 months.

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