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Nat Neurosci. 2001 Sep;4(9):873-4.

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.

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  • 1Department of Biology, GlaxoSmithKline Laboratories, via Fleming 4, 37100 Verona, Italy.

Abstract

Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.

PMID:
11528416
[PubMed - indexed for MEDLINE]
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