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Nat Neurosci. 2001 Sep;4(9):871-2.

Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity.

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  • 1Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Building 49, Room 5A38, National Institutes of Health, Bethesda, Maryland 20892, USA.


A compartmental nerve-muscle tissue culture system expresses Hebbian activity-dependent synapse modulation. Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that protein kinase A (PKA) is involved in homosynaptic stabilization. Both work through postsynaptic changes in the acetylcholine receptor (AChR) as measured electrophysiologically and by imaging techniques.

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