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Nat Genet. 2001 Sep;29(1):23-4.

PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients.

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  • 1Department of Neurology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.


A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.

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