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Bioorg Med Chem Lett. 2001 Sep 3;11(17):2253-6.

Optimization of a screening lead for factor VIIa/TF.

Author information

  • 1Department of Medicinal Chemistry, Axys Pharmaceuticals, Inc., 385 Oyster Point Blvd., South San Francisco, CA 94080, USA. wendy_young@axyspharm.com

Abstract

The structure-based design and progression of a screening lead to a 3nM factor VIIa/TF inhibitor with improved selectivity versus related enzymes is described.

PMID:
11527709
[PubMed - indexed for MEDLINE]
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