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Diabetes Care. 2001 Sep;24(9):1640-5.

Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men.

Author information

  • 1Department of Public Health and Clinical Medicine, Umeå University Hospital, 901 85 Umeå, Sweden. eva.rask@medicin.umu.se

Abstract

OBJECTIVE:

To investigate whether features of the insulin resistance syndrome are associated with altered incretin responses to food intake.

RESEARCH DESIGN AND METHODS:

From a population-based study, 35 men were recruited, representing a wide spectrum of insulin sensitivity and body weight. Each subject underwent a hyperinsulinemic-euglycemic clamp to determine insulin sensitivity. A mixed meal was given, and plasma levels of gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), as well as insulin, glucagon, and glucose were measured.

RESULTS:

Insulin resistance was associated with impaired GIP and GLP-1 responses to a mixed meal. The total area under the curve (AUC) of the GIP response after the mixed meal was associated with insulin sensitivity (r = 0.54, P < 0.01). There was a significant difference between the highest and the lowest tertile of insulin sensitivity (P < 0.05). GLP-1 levels 15 min after food intake were significantly lower in the most insulin-resistant tertile compared with the most insulin-sensitive tertile. During the first hour, the AUC of GLP-1 correlated significantly with insulin sensitivity (r = 0.47, P < 0.01). Multiple linear regression analysis showed that insulin resistance, but not obesity, was an independent predictor of these decreased incretin responses.

CONCLUSIONS:

In insulin resistance, the GIP and GLP-1 responses to a mixed meal are impaired and are related to the degree of insulin resistance. Decreased incretin responsiveness may be of importance for the development of impaired glucose tolerance.

PMID:
11522713
[PubMed - indexed for MEDLINE]
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