Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S98-102.

Hyperforin--antidepressant activity by a novel mechanism of action.

Author information

  • 1Department of Pharmacology, University of Frankfurt, Frankfurt/M., Germany.

Abstract

Hyperforin represents a major antidepressive constituent of St. John's wort (SJW) extract. It not only inhibits the neuronal uptake of serotonin, norepinephrine and dopamine like many other antidepressants, but also inhibits GABA and L-glutamate uptake. This broad-spectrum effect is obtained by an elevation of the intracellular Na+ concentration, probably due to activation of sodium conductive pathways not yet finally identified but most likely ionic channels. This makes hyperforin the first member of a new class of compounds with a preclinical antidepressant profile due to a completely novel mechanism of action.

PMID:
11518085
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk