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Curr Biol. 2001 Jun 5;11(11):R419-22.

Motile organelles: the importance of specific tubulin isoforms.

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  • Department of Genetics, Washington University School of Medicine, 660 s. Euclid, St. Louis, Missouri 63110, USA. dutcher@genetics.wuustl.edu


The requirements for building flagellar axonemes and centrioles are beginning to be uncovered. The carboxyl terminus of a specific beta tubulin isoform plays an important role in forming the '9 + 2' structure of the axoneme; delta tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.

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