Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Chem Biol. 2001 Aug;8(8):739-58.

Proteasome inhibitors: from research tools to drug candidates.

Author information

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA. alexei_kisselev@hms.harvard.edu


The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex, which degrades the majority of cellular polypeptides by an unusual enzyme mechanism. Several groups of proteasome inhibitors have been developed and are now widely used as research tools to study the role of the ubiquitin-proteasome pathway in various cellular processes, and two inhibitors are now in clinical trials for treatment of multiple cancers and stroke.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk