Semin Cancer Biol. 2001 Aug;11(4):297-306.

Tumour dormancy: findings and hypotheses from clinical research on breast cancer.

Source

Direzione Sanitaria, Istituto Nazionale Tumori, Via Venezian 1, 20137 Milan, Italy. demicheli@anprosc.anapat.istitutotumori.mi.it

Abstract

Breast cancer metastatic development is commonly considered as resulting from continuous tumour growth from tumour seeding until clinical recurrence is documented. Continuous growth model inferences, however, fail to explain clinical findings concerning local recurrences, as well as the time-distribution of first treatment failure and mortality for patients undergoing mastectomy. The tumour dormancy hypothesis is considered to provide a more reasonable description of the natural history of breast cancer, while primary tumour removal is believed to be a potential perturbing factor for metastasis development. A new model of the natural history of operable breast cancer, incorporating tumour dormancy and starting signals from surgery for micrometastatic growth is proposed.

PMID:: 11513565; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Breast Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Proposal for a new model of breast cancer metastatic development. [Ann Oncol. 1997]
Review Proposal for a new model of breast cancer metastatic development.
Demicheli R, Retsky MW, Swartzendruber DE, Bonadonna G. Ann Oncol. 1997 Nov; 8(11):1075-80.
Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour. [Breast Cancer Res. 2004]
Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour.
Demicheli R, Bonadonna G, Hrushesky WJ, Retsky MW, Valagussa P. Breast Cancer Res. 2004; 6(6):R689-96. Epub 2004 Oct 11.
Review Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures. [Nat Clin Pract Oncol. 2007]
Review Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures.
Demicheli R, Retsky MW, Hrushesky WJ, Baum M. Nat Clin Pract Oncol. 2007 Dec; 4(12):699-710.
Putative growth characteristics of micrometastatic breast cancer. [Breast Cancer Res. 2008]
Putative growth characteristics of micrometastatic breast cancer.
Chambers AF, Goss PE. Breast Cancer Res. 2008; 10(6):114. Epub 2008 Nov 27.
Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process. [Ann Oncol. 2005]
Breast cancer recurrence dynamics following adjuvant CMF is consistent with tumor dormancy and mastectomy-driven acceleration of the metastatic process.
Demicheli R, Miceli R, Moliterni A, Zambetti M, Hrushesky WJ, Retsky MW, Valagussa P, Bonadonna G. Ann Oncol. 2005 Sep; 16(9):1449-57. Epub 2005 Jun 14.

See reviews... See all...

Cited by 17 PubMed Central articles

Implications of bone-only metastases in breast cancer: favorable preference with excellent outcomes of hormone receptor positive breast cancer. [Cancer Res Treat. 2011]
Implications of bone-only metastases in breast cancer: favorable preference with excellent outcomes of hormone receptor positive breast cancer.
Lee SJ, Park S, Ahn HK, Yi JH, Cho EY, Sun JM, Lee JE, Nam SJ, Yang JH, Park YH, et al. Cancer Res Treat. 2011 Jun; 43(2):89-95. Epub 2011 Jun 30.
The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium. [PLoS One. 2011]
The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium.
Phillips JE, Huang E, Shaulsky G, Gomer RH. PLoS One. 2011; 6(7):e21765. Epub 2011 Jul 7.
Review Controversies in clinical cancer dormancy. [Proc Natl Acad Sci U S A. 2011]
Review Controversies in clinical cancer dormancy.
Uhr JW, Pantel K. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12396-400. Epub 2011 Jul 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tumour dormancy: findings and hypotheses from clinical research on breast cancer...
Tumour dormancy: findings and hypotheses from clinical research on breast cancer.
Semin Cancer Biol. 2001 Aug ;11(4):297-306.

PubMed
Alcoholism and the hyperactive child syndrome.
Alcoholism and the hyperactive child syndrome.
J Nerv Ment Dis. 1975 May ;160(5):349-53.

PubMed
Ear-lobe keloids: treatment by a protocol of surgical excision and immediate pos...
Ear-lobe keloids: treatment by a protocol of surgical excision and immediate postoperative adjuvant radiotherapy.
Br J Plast Surg. 2001 Sep ;54(6):504-8.

PubMed
Factor analy of orality and anality in selected patient groups.
Factor analy of orality and anality in selected patient groups.
J Nerv Ment Dis. 1975 May ;160(5):311-23.

PubMed
Radon exposure and the risk of leukemia: a review of epidemiological studies.
Radon exposure and the risk of leukemia: a review of epidemiological studies.
Health Phys. 2001 Sep ;81(3):272-88.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: