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Phytother Res. 2001 Aug;15(5):441-3.

Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum).

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  • 1Department of Plant Science, Cook College, Rutgers University, New Brunswick, NJ 08903, USA.


Four pyranocoumarins; dipetaline, alloxanthoxyletin, xanthoxyletin and xanthyletin; and two lignans; sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all inhibited the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. Dipetaline was the most active with an IC(50) of 0.68 ppm, followed by alloxanthoxyletin (1.31 ppm), sesamin (2.71 ppm), asarinin (4.12 ppm), xanthoxyletin (3.48 ppm) and xanthylletin (3.84 ppm).

Copyright 2001 John Wiley & Sons, Ltd.

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