Eur J Gastroenterol Hepatol. 2001 Aug;13(8):889-90.

Telomeres and telomerases: intimations of immortality.

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Department of Cellular Pathology, Birmingham Heartlands Hospital, Birmingham, UK. crockej@heartsol.wmids.nhs.uk

Abstract

There is a constant balance in cancer cells between division and death. The malignant phenotype is associated with a continuing cell cycle or 'immortalization'. Telomeres, structures that cap the chromosomes, are related to cell longevity and are regulated by a ribonucleoprotein called telomerase. This review describes the possible roles of telomeres and telomerase in the malignant process.

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Eur J Gastroenterol Hepatol. 2001 Aug;13(8):903-8.

PMID:: 11507350; [PubMed - indexed for MEDLINE]

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