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Trends Biochem Sci. 2001 Aug;26(8):504-10.

The glucose-regulated proteins: stress induction and clinical applications.

Author information

  • 1University of Southern California/Norris Comprehensive Cancer Center, Dept of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. amylee@hsc.usc.edu

Abstract

A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

PMID:
11504627
[PubMed - indexed for MEDLINE]
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