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Trends Biochem Sci. 2001 Aug;26(8):482-9.

Coordination of Ca2+ signalling by NAADP.

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  • 1Dept of Pharmacology, University of Oxford, Mansfield Road, OX1 3QT, Oxford, UK.


Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes intracellular Ca2+ stores in several cell types. Ample evidence suggests that NAADP activates intracellular Ca2+ channels distinct from those that are sensitive to inositol trisphosphate and ryanodine/cyclic ADP-ribose. Recent studies in intact cells have demonstrated functional coupling ('channel chatter') between Ca2+ release pathways mediated by NAADP, inositol trisphosphate and cyclic ADP-ribose. Thus, NAADP is probably an important determinant in shaping cytosolic Ca2+ signals.

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