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Infect Immun. 2001 Sep;69(9):5940-2.

Cryptosporidium parvum infection requires host cell actin polymerization.

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  • 1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.


The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

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