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Membr Cell Biol. 2001;14(4):429-61.

The role of sphingosine and its derivatives in the regulation of Ca2+ homeostasis.

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  • 1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow. olgavek@yandex.ru


The role of sphingosine and sphingosine 1-phosphate in the regulation of Ca2+ homeostasis is reviewed. Available data suggest that there are at least three main pathways by which sphingosine and its metabolites affect Ca2+ fluxes in different cell types: (1) indirect action on Ca2+ stores, mediated by other transduction pathways; (2) direct action on the receptors of Ca2+ channels and Ca2+ pumps which are localized at the membranes of Ca2+ stores; (3) indirect action mediated by the regulation of expression of the channel-forming protein Bcl-2, which incorporates into membranes of Ca2+ stores. The effects of sphingosine and its metabolites on Ca2+ homeostasis via mechanisms (1)-(3) are considered. The combination of the mechanisms by which sphingosine affects Ca2+-signalling pathways is tissue-specific. Sphingosine and its metabolites can be physiological modulators of the intracellular Ca2+ signalling pathways.

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