Neuroreport. 2001 Aug 8;12(11):2595-9.

Addiction changes orbitofrontal gyrus function: involvement in response inhibition.

Goldstein RZ, Volkow ND, Wang GJ, Fowler JS, Rajaram S.

Source

Brookhaven National Laboratory, Medical Research, Bldg. 490, 30 Bell Ave, Upton, NY 11973, USA.

Abstract

We used the Stroop task as a measure of the ability to inhibit a prepotent response tendency and examined its association with relative glucose metabolism in selected prefrontal brain regions in cocaine addicts, alcoholics, and controls (17 per group). Results revealed that for the substance abusers, higher orbitofrontal gyrus (OFG) activation was associated with lower conflict (higher score; r = 0.32, p < 0.05). For the controls, higher OFG activation was associated with higher conflict (lower score; r = -0.42, p < 0.05). Thus, at baseline, increased relative activation of the OFG is associated with worse performance in controls and better performance in substance abusers on the Stroop task, suggesting reversal of the role of the OFG as a function of addiction.

PMID:: 11496155; [PubMed - indexed for MEDLINE]
PMCID:: PMC1201131

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. [Neuropsychologia. 2004]
Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex.
Goldstein RZ, Leskovjan AC, Hoff AL, Hitzemann R, Bashan F, Khalsa SS, Wang GJ, Fowler JS, Volkow ND. Neuropsychologia. 2004; 42(11):1447-58.
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. [Am J Psychiatry. 1999]
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction.
Volkow ND, Wang GJ, Fowler JS, Hitzemann R, Angrist B, Gatley SJ, Logan J, Ding YS, Pappas N. Am J Psychiatry. 1999 Jan; 156(1):19-26.
Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification. [Alcohol Clin Exp Res. 1997]
Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification.
Volkow ND, Wang GJ, Overall JE, Hitzemann R, Fowler JS, Pappas N, Frecska E, Piscani K. Alcohol Clin Exp Res. 1997 Oct; 21(7):1278-84.
Review Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. [J Psychopharmacol. 1999]
Review Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans.
Volkow ND, Fowler JS, Wang GJ. J Psychopharmacol. 1999 Dec; 13(4):337-45.
Review Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. [Am J Psychiatry. 2002]
Review Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.
Goldstein RZ, Volkow ND. Am J Psychiatry. 2002 Oct; 159(10):1642-52.

See reviews... See all...

Cited by 18 PubMed Central articles

Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. [Front Neurol. 2012]
Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury.
Irimia A, Chambers MC, Torgerson CM, Filippou M, Hovda DA, Alger JR, Gerig G, Toga AW, Vespa PM, Kikinis R, et al. Front Neurol. 2012; 3:10. Epub 2012 Feb 6.
Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. [Front Psychiatry. 2011]
Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration.
Acosta G, Freidman DP, Grant KA, Hemby SE. Front Psychiatry. 2011; 2:72. Epub 2012 Jan 3.
Brain response to a humanoid robot in areas implicated in the perception of human emotional gestures. [PLoS One. 2010]
Brain response to a humanoid robot in areas implicated in the perception of human emotional gestures.
Chaminade T, Zecca M, Blakemore SJ, Takanishi A, Frith CD, Micera S, Dario P, Rizzolatti G, Gallese V, Umiltà MA. PLoS One. 2010 Jul 21; 5(7):e11577. Epub 2010 Jul 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Addiction changes orbitofrontal gyrus function: involvement in response inhibiti...
Addiction changes orbitofrontal gyrus function: involvement in response inhibition.
Neuroreport. 2001 Aug 8 ;12(11):2595-9.

PubMed
Dynamic magnetic resonance imaging defecography: a diagnostic alternative in the...
Dynamic magnetic resonance imaging defecography: a diagnostic alternative in the assessment of pelvic floor disorders in proctology.
Dis Colon Rectum. 2001 Jul ;44(7):999-1007.

PubMed
Commentary: considerations for use of racial/ethnic classification in etiologic ...
Commentary: considerations for use of racial/ethnic classification in etiologic research.
Am J Epidemiol. 2001 Aug 15 ;154(4):291-8.

PubMed
Complications of femoral and subclavian venous catheterization in critically ill...
Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial.
JAMA. 2001 Aug 8 ;286(6):700-7.

PubMed
Itraconazole pulse therapy for the treatment of Candida onychomycosis.
Itraconazole pulse therapy for the treatment of Candida onychomycosis.
J Eur Acad Dermatol Venereol. 2001 Mar ;15(2):112-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: