Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Nephrol Hypertens. 2001 Sep;10(5):611-6.

Nocturnal non-dipping: what does it augur?

Author information

  • 1Integrative and Behavioral Cardiology Program, PO Box 1030, Mount Sinai Medical Center, New York, New York 10029-6574, USA. thomas.pickering@msnyuhealth.org

Abstract

The non-dipping pattern of blood pressure (defined as a nocturnal fall of less than 10%) occurs in about 25% of hypertensives, with increased prevalence in certain sub-groups such as diabetics, African-Americans, and patients with renal disease. It almost certainly has multiple causes, including factors such as the levels of activity and arousal during both the day and the night, the depth and quality of sleep, and the activity of the sympathetic nervous system, among others. In patients with uncomplicated hypertension, the reproducibility is relatively low. There is evidence suggesting that the non-dipping pattern may have an adverse prognosis: thus, it appears to predict the progression of renal disease, to be associated with increased target-organ damage (in some studies), and also to predict increased cardiovascular morbidity. Antihypertensive drug treatment can normalize the non-dipping pattern, but the therapeutic consequences of this are unknown.

PMID:
11496054
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk