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BMC Med Genet. 2001;2:8. Epub 2001 Jul 24.

Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study.

Author information

  • 1St Petersburg State Medical University, Laboratory of Molecular Cardiology, L Tolstoy St, 6/8, St Petersburg, 197189, Russia. nshch@yahoo.com

Abstract

BACKGROUND:

The gene encoding apolipoprotein E (APOE) has been proposed as a candidate gene for vascular complications in Type I diabetes. This study aimed to investigate the influence of three-allelic variations in the APOE gene for the development of diabetic retinopathy and nephropathy.

RESULTS:

Neither APOE alleles frequencies or APOE genotypes frequencies differed between Type I diabetic groups either with or without nephropathy. Similar results were found for patients with and without diabetic retinopathy.

CONCLUSIONS:

APOE gene polymorphism does not determine genetic susceptibility for the development of diabetic retinopathy in Type I diabetes patients. Association between APOE gene polymorphism and diabetic nephropathy may be weak or moderate, but not strong.

PMID:
11495633
[PubMed]
PMCID:
PMC37310
Free PMC Article
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