Identification of the first trans-(3R,4R)- dimeth... [J Med Chem. 2001] - PubMed

Save items

loading

Related citations in PubMed

Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist. [J Med Chem. 2003]
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
Thomas JB, Atkinson RN, Vinson NA, Catanzaro JL, Perretta CL, Fix SE, Mascarella SW, Rothman RB, Xu H, Dersch CM, et al. J Med Chem. 2003 Jul 3; 46(14):3127-37.
Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). [J Med Chem. 2008]
Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
Cai TB, Zou Z, Thomas JB, Brieaddy L, Navarro HA, Carroll FI. J Med Chem. 2008 Mar 27; 51(6):1849-60. Epub 2008 Feb 29.
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine. [J Med Chem. 1998]
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.
Thomas JB, Fall MJ, Cooper JB, Rothman RB, Mascarella SW, Xu H, Partilla JS, Dersch CM, McCullough KB, Cantrell BE, et al. J Med Chem. 1998 Dec 17; 41(26):5188-97.
Review New delta-opioid antagonists as pharmacological probes. [Trends Pharmacol Sci. 1998]
Review New delta-opioid antagonists as pharmacological probes.
Bryant SD, Salvadori S, Cooper PS, Lazarus LH. Trends Pharmacol Sci. 1998 Feb; 19(2):42-6.
Review Kappa opioid antagonists: past successes and future prospects. [AAPS J. 2005]
Review Kappa opioid antagonists: past successes and future prospects.
Metcalf MD, Coop A. AAPS J. 2005 Oct 27; 7(3):E704-22. Epub 2005 Oct 27.

See reviews... See all...

Cited by 16 PubMed Central articles

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. [ACS Chem Neurosci. 2012]
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.
Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, et al. ACS Chem Neurosci. 2012 Mar 21; 3(3):221-236. Epub 2012 Jan 20.
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety. [Addict Biol. 2012]
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.
Schank JR, Goldstein AL, Rowe KE, King CE, Marusich JA, Wiley JL, Carroll FI, Thorsell A, Heilig M. Addict Biol. 2012 May; 17(3):634-47.
Structure of the human κ-opioid receptor in complex with JDTic. [Nature. 2012]
Structure of the human κ-opioid receptor in complex with JDTic.
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, et al. Nature. 2012 Mar 21; 485(7398):327-32. Epub 2012 Mar 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioAssay
PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidin...
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.
J Med Chem. 2001 Aug 16 ;44(17):2687-90.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Chemical Information

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by 16 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information