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Thromb Haemost. 2001 Jul;86(1):276-88.

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen.

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  • 1Department of Pharmacology, University of Oxford, UK. steve.watson@pharm.ox.ac.uk

Abstract

The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

PMID:
11487016
[PubMed - indexed for MEDLINE]
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