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Nat Rev Neurosci. 2001 Aug;2(8):577-88.

Pathophysiology of levodopa-induced dyskinesia: potential for new therapies.

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  • 1Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, UniversitĂ© Victor Segalen Bordeaux 2, 146 rue LĂ©o Saignat, 33076 Bordeaux Cedex, France.


Involuntary movements--or dyskinesias--are a debilitating complication of levodopa therapy for Parkinson's disease, and is experienced in most patients. Despite the importance of this problem, little was known about the cause of dyskinesia until recently; however, this situation has changed significantly in the past few years. Our increased understanding of levodopa-induced dyskinesia is not only valuable for improving patient care, but also in providing us with new insights into the functional organization of the basal ganglia and motor systems.

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