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Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609.

Transcriptional regulation by the phosphorylation-dependent factor CREB.

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  • 1Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.


The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?

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