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1: Farmaco. 2001 May-Jul;56(5-7):383-5.Click here to read Links

M1 receptor activation is a requirement for arecoline analgesia.

Ghelardini C, Galeotti N, Lelli C, Bartolini A.

Department of Pharmacology, University of Florence, Italy. ghelard@server1.pharm.unifi.it

Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.). A dose-dependent inhibition of the antinociception induced by arecoline was observed after inactivation of the M1 gene by an antisense oligodeoxyribonucleotide (aODN). This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors.

PMID: 11482763 [PubMed - indexed for MEDLINE]