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Int Orthop. 2001;25(3):164-6.

Kashin-Beck disease and iodine deficiency in Tibet.

Author information

  • 1Department of Nuclear Medicine, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.be

Abstract

We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.

PMID:
11482533
[PubMed - indexed for MEDLINE]
PMCID:
PMC3620653
Free PMC Article
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