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News Physiol Sci. 2001 Aug;16:171-3.

Molecular recognition by induced fit: how fit is the concept?

Author information

  • Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland.

Abstract

Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.

PMID:
11479367
[PubMed - indexed for MEDLINE]
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