Lipoxins: revelations on resolution. [Trends Pharmacol Sci. 2001]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 1

Click to change filter selection through MyNCBI.

1: Trends Pharmacol Sci. 2001 Aug;22(8):391-5. Links

Lipoxins: revelations on resolution.

McMahon B, Mitchell S, Brady HR, Godson C.

Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.

Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, "pro-resolution" actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed.

PMID: 11478982 [PubMed - indexed for MEDLINE]

ReviewLipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution.
Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):141-62.

[Prostaglandins Leukot Essent Fatty Acids. 2005]
Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.
J Exp Med. 1997 May 5; 185(9):1693-704.

[J Exp Med. 1997]
ReviewLipoxins: novel anti-inflammatory therapeutics?
Curr Opin Investig Drugs. 2000 Nov; 1(3):380-5.

[Curr Opin Investig Drugs. 2000]
ReviewLiver: the formation and actions of aspirin-triggered lipoxins.
Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):277-82.

[Prostaglandins Leukot Essent Fatty Acids. 2005]
ReviewLipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?
Prostaglandins. 1997 Feb; 53(2):107-37.

[Prostaglandins. 1997]
» See reviews... | » See all...

Cited by 5 PubMed Central articles

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.
Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. J Exp Med. 2005 Mar 7; 201(5):713-22.

[J Exp Med. 2005]
Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells.
Mitchell D, Rodgers K, Hanly J, McMahon B, Brady HR, Martin F, Godson C. Am J Pathol. 2004 Mar; 164(3):937-46.

[Am J Pathol. 2004]
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.
Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJ. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2135-9. Epub 2004 Feb 6.

[Proc Natl Acad Sci U S A. 2004]
» See all...

Patient Drug Information

Aspirin (Adprin B® Tri-Buffered Caplets® , Alka-Seltzer® Effervescent Pain Reliever and Antacid, Alka-Seltzer® Extra Strength Effervescent Pain Reliever and Antacid, ...)
Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemi...
Source: AHFS Consumer Medication Information

Recent Activity

Clear Turn Off Turn On

Lipoxins: revelations on resolution.Lipoxins: revelations on resolution.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

Lipoxins: revelations on resolution.

Related articles

Cited by 5 PubMed Central articles

Patient Drug Information

Recent Activity