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[Blocking action of tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta].

[Article in Chinese]

Author information

  • 1Burn Center, First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006.

Abstract

OBJECTIVE:

To investigate the effect of Tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta (TGF-beta).

METHODS:

The scar-derived fibroblasts were suspended in a solution of collagen matrix, and TGF-beta, they were associated to form a scar model in vitro. The influence of tetrandrine on the contraction indexes was observed.

RESULTS:

Tetrandrine plays a blocking action in the scar-collagen matrix contraction stimulated by TGF-beta, which was in a dose-dependent manner.

CONCLUSION:

This function of tetrandrine could be responsible for the anti-scar mechanism.

PMID:
11477822
[PubMed - indexed for MEDLINE]
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