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Cytogenet Cell Genet. 2001;93(1-2):40-2.

Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC).

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  • 1Department of Pharmaco-Biology, University of Bari, via Orabona 4, 70125 Bari, Italy.

Abstract

The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochondria and is therefore essential for mtDNA synthesis. The human DNC gene (SLC25A19) spans about 16.5 kb and consists of nine exons with the translation start site in exon 4. It is located on chromosome 17q25.3. Three transcripts, which differ in their 5' ends and are generated by alternative splicing, have been identified.

Copyright 2001 S. Karger AG, Basel

PMID:
11474176
[PubMed - indexed for MEDLINE]
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