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Kidney Int. 2001 Aug;60(2):462-5.

Phosphorylation of a new member of the bicarbonate cotransporter superfamily.

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  • Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan. matuhiko@mc.med.keio.ac.jp


Acid-base balance is regulated by cortical collecting duct cells in kidney, where the transporter functions of beta-intercalated cells are controlled by such factors as isoproterenol, cyclic adenosine monophosphate (cAMP), and the protein kinase A (PKA) pathway. The apical anion exchanger (AE) in beta-intercalated cells is thought to be involved in the secretion of bicarbonate into urine. In isolated cells, the Cl- channel was shown to be activated by isoproterenol via the PKA pathway. The importance of the PKA pathway and phosphorylation in the regulation of its transporter activity is not yet known.

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