Ultrastruct Pathol. 2001 May-Jun;25(3):183-92.

Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells.

Gilloteaux J, Jamison JM, Arnold D, Taper HS, Summers JL.

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Department of Anatomy, Lake Erie College of Osteopathic Medicine, Pennsylvania 16509-1025, USA. jgilloteaux@lecom.edu

Abstract

Scanning and transmission electron microscopy were employed to further characterize the cytotoxic effects of a ascorbic acid/menadione (or vitamin C/vitamin K3) combination on a human bladder carcinoma T24 cell line. Following 1-h treatment T24 cells display membrane and mitochondrial defects as well as excision of cytoplasmic fragments that contain no organelles. These continuous self-excisions reduce the cell size. Concomitant, nuclear changes, chromatin disassembly, nucleolar condensation and fragmentation, and decreased nuclear volume lead to cell death via a process similar to karyorrhexis and karyolysis. Because this cell death is achieved through a progressive loss of cytoplasm due to self-morsellation, the authors named this mode of cell death autoschizis (from the Greek autos, self, and schizein, to split, as defined in Scanning. 1998; 20: 564-575). This morphological characterization of autoschizic cell death confirms and extends the authors previous reports and demonstrates that this cell death is distinct from apoptosis.

PMID:: 11465474; [PubMed - indexed for MEDLINE]

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Autoschizis: another cell death for cancer cells induced by oxidative stress. [Ital J Anat Embryol. 2001]
Autoschizis: another cell death for cancer cells induced by oxidative stress.
Gilloteaux J, Jamison JM, Arnold D, Summers JL. Ital J Anat Embryol. 2001; 106(2 Suppl 1):79-92.
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Review Autoschizis: a novel cell death. [Biochem Pharmacol. 2002]
Review Autoschizis: a novel cell death.
Jamison JM, Gilloteaux J, Taper HS, Calderon PB, Summers JL. Biochem Pharmacol. 2002 May 15; 63(10):1773-83.

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Cited by 2 PubMed Central articles

Nucleolar changes and fibrillarin redistribution following apatone treatment of human bladder carcinoma cells. [J Histochem Cytochem. 2010]
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Jamison JM, Gilloteaux J, Perlaky L, Thiry M, Smetana K, Neal D, McGuire K, Summers JL. J Histochem Cytochem. 2010 Jul; 58(7):635-51. Epub 2010 Apr 12.
alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate. [Br J Cancer. 2010]
alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate.
Tomasetti M, Strafella E, Staffolani S, Santarelli L, Neuzil J, Guerrieri R. Br J Cancer. 2010 Apr 13; 102(8):1224-34. Epub 2010 Mar 23.

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