Format

Send to:

Choose Destination
See comment in PubMed Commons below

Role of mitochondria in amyotrophic lateral sclerosis.

Author information

  • 1Department of Neurology, University of Virginia Health System, Charlottesville 22908, USA. rhs7e@virginia.edu

Abstract

Neurodegeneration in amyotrophic lateral sclerosis (ALS) is characterized by the specific loss of central and peripheral motor neurons. While this pattern of neuronal demise gives rise to a distinct clinical syndrome, at the cellular and molecular level ALS pathology is similar to that seen in other neurodegenerative diseases. In particular, mitochondrial dysfunction in ALS is reminiscent of that observed in Alzheimer's and Parkinson's diseases. Mitochondria in persons with ALS demonstrate impaired electron transport, increased free radical generation, and an inability to adequately buffer cytosolic calcium shifts. These abnormalities are probably systemic and potentially due to mutation of mitochondrial DNA.

Comment in

  • Role of mitochondria in ALS. [Amyotroph Lateral Scler Other Motor Neuron Disord. 2000]
PMID:
11464951
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk