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Nature. 2001 Jun 14;411(6839):843-7.

Natural products and plant disease resistance.

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  • 1Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA.


Plants elaborate a vast array of natural products, many of which have evolved to confer selective advantage against microbial attack. Recent advances in molecular technology, aided by the enormous power of large-scale genomics initiatives, are leading to a more complete understanding of the enzymatic machinery that underlies the often complex pathways of plant natural product biosynthesis. Meanwhile, genetic and reverse genetic approaches are providing evidence for the importance of natural products in host defence. Metabolic engineering of natural product pathways is now a feasible strategy for enhancement of plant disease resistance.

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