Abstract
The protective effects of eleven Salvia species native to Europe against enzyme-dependent and enzyme-independent lipid peroxidation were evaluated. The 50% aqueous methanolic extracts of the leaves of all tested plants were found to be more effective than the positive control alpha-tocopherol acid succinate. The extracts of S. candelabrum, S. ringens, S. tomentosa, S. nemorosa, and S. glutinosa displayed considerable concentration-dependent antioxidative effects that were comparable to those of the medicinal and aromatic plant S. officinalis. The concentrations of flavonoids, hydroxycinnamic acids and total phenolic compounds in each extract were quantified with the aim of clarifying the connection between activity and chemical composition.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Brain / drug effects
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Brain / enzymology
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Cattle
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Cinnamates / isolation & purification*
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Cinnamates / pharmacology
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Coumaric Acids / isolation & purification*
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Coumaric Acids / pharmacology
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Depsides
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Dose-Response Relationship, Drug
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Lipid Peroxidation / drug effects
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Plant Leaves / chemistry*
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Plants, Medicinal / chemistry*
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Rats
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Rosmarinic Acid
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Structure-Activity Relationship
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Tocopherols
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Vitamin E / analogs & derivatives*
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Vitamin E / pharmacology
Substances
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Antioxidants
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Cinnamates
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Coumaric Acids
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Depsides
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Flavonoids
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Plant Extracts
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Vitamin E
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Tocopherols