Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2001 Jul 13;293(5528):297-300.

Molecular evolution of protein atomic composition.

Author information

  • 1Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, 91 198 Gif-sur-Yvette Cedex, France., Evologic SA, 4 rue Pierre Fontaine, 91000 Evry, France.


Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological imprints. Significant correlations between atomic composition and metabolic function were found in sulfur- and carbon-assimilatory enzymes, which appear depleted in sulfur and carbon, respectively, in both the bacterium Escherichia coli and the eukaryote Saccharomyces cerevisiae. In addition to genetic instructions, genomic data thus also provide paleontological records of environmental nutrient availability and of metabolic costs.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk