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Jpn J Clin Oncol. 2001 May;31(5):226-30.

Mucinous adenocarcinoma of Bartholin gland treated with radiation therapy: a case report.

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  • 1Division of Radiation Medicine, National Institute of Radiological Sciences, NIRS, Chiba, Japan.


Adenocarcinoma of Bartholin gland is a very rare disease and its molecular pathological features are poorly delineated. A 92-year-old woman with mucinous adenocarcinoma of Bartholin gland with metastasis to the right inguinal lymph node was treated with radiation therapy alone. Despite intensive radiation therapy, the tumor was locally recurrent and the patient died 10 months after radiation therapy. We searched for the presence of human papillomavirus 16 and 18 DNA and the expression of p53 protein, CA19-9, CEA and MIB-1 antigen. Immunohistochemical study showed that mucinous adenocarcinoma of Bartholin gland produced CA19-9 and CEA.

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