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Am J Surg. 2001 May;181(5):431-3.

Genetic counseling impacts decision for prophylactic surgery for patients perceived to be at high risk for breast cancer.

Author information

  • 1Department of Surgery, Oregon Health Sciences University, and Legacy Cancer Services, 1130 NW 22nd, Suite 500, Portland, OR 97210, USA.

Abstract

BACKGROUND:

This study addresses the impact a comprehensive genetic counseling program had on women considering prophylactic mastectomy or oophorectomy.

METHODS:

Sixty patients underwent detailed family evaluation and risk was estimated. Recommendations were made regarding testing. Ramifications of testing were discussed in detail.

RESULTS:

Thirty-one women (37%) were considering prophylactic surgery believing themselves to be at high risk. Of these, 23 had testing recommended. Seven patients proceeded with prophylactic surgery based solely on high-risk assessment. Ten women were tested; five were positive. Three patients proceeded with prophylactic surgery despite a negative test. One decided against surgery despite a positive test. After counseling, prophylactic surgery was performed in just over half the initial candidates.

CONCLUSIONS:

Breast cancer risk estimation and genetic evaluation can be complex. Comprehensive genetic risk assessment programs can play a significant role in the management of patients considering prophylactic surgery for perceived high risk.

PMID:
11448436
[PubMed - indexed for MEDLINE]
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