Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Am J Surg. 2001 May;181(5):431-3.

Genetic counseling impacts decision for prophylactic surgery for patients perceived to be at high risk for breast cancer.

Author information

  • 1Department of Surgery, Oregon Health Sciences University, and Legacy Cancer Services, 1130 NW 22nd, Suite 500, Portland, OR 97210, USA.



This study addresses the impact a comprehensive genetic counseling program had on women considering prophylactic mastectomy or oophorectomy.


Sixty patients underwent detailed family evaluation and risk was estimated. Recommendations were made regarding testing. Ramifications of testing were discussed in detail.


Thirty-one women (37%) were considering prophylactic surgery believing themselves to be at high risk. Of these, 23 had testing recommended. Seven patients proceeded with prophylactic surgery based solely on high-risk assessment. Ten women were tested; five were positive. Three patients proceeded with prophylactic surgery despite a negative test. One decided against surgery despite a positive test. After counseling, prophylactic surgery was performed in just over half the initial candidates.


Breast cancer risk estimation and genetic evaluation can be complex. Comprehensive genetic risk assessment programs can play a significant role in the management of patients considering prophylactic surgery for perceived high risk.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk