Neuroreport. 2001 Jul 20;12(10):2155-8.

The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine.

Lindblom J, Opmane B, Mutulis F, Mutule I, Petrovska R, Klusa V, Bergström L, Wikberg JE.

Source

Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, Box 591, BMC, SE-751 24 Uppsala, Sweden.

Abstract

Strong evidence suggests a functional link between the melanocortin and dopamine systems. alpha-Melanocyte stimulating hormone (alpha-MSH) induced grooming behaviour, which can be blocked by dopamine receptor antagonists, is associated with increased dopaminergic transmission in the striatal regions. Whether this effect is mediated specifically by melanocortin (MC) receptors has not previously been established. Using in vivo microdialysis on anesthesized rats we have shown that alpha- MSH administered into the ventral tegmental area induced a significant increase in dopamine and DOPAC levels in the nucleus accumbens. This increase was completely blocked by pre-treatment with the MC4 receptor selective antagonist HS131, indicating that the effects of alpha-MSH on dopamine transmission may be mediated by the MC4 receptor.

PMID:: 11447325; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Correlation of increased grooming behavior and motor activity with alterations in nigrostriatal and mesolimbic catecholamines after alpha-melanotropin and neuropeptide glutamine-isoleucine injection in the rat ventral tegmental area. [Cell Mol Neurobiol. 2001]
Correlation of increased grooming behavior and motor activity with alterations in nigrostriatal and mesolimbic catecholamines after alpha-melanotropin and neuropeptide glutamine-isoleucine injection in the rat ventral tegmental area.
Sánchez MS, Barontini M, Armando I, Celis ME. Cell Mol Neurobiol. 2001 Oct; 21(5):523-33.
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. [Eur J Pharmacol. 1999]
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.
Adan RA, Szklarczyk AW, Oosterom J, Brakkee JH, Nijenhuis WA, Schaaper WM, Meloen RH, Gispen WH. Eur J Pharmacol. 1999 Aug 13; 378(3):249-58.
Evidence that alpha-MSH induced grooming is not primarily mediated by any of the cloned melanocortin receptors. [Neuropeptides. 2000]
Evidence that alpha-MSH induced grooming is not primarily mediated by any of the cloned melanocortin receptors.
Sanchez MS, Celis ME, Schiöth HB. Neuropeptides. 2000 Apr; 34(2):77-82.
Review Melanocortins and opiate addiction. [Life Sci. 1997]
Review Melanocortins and opiate addiction.
Alvaro JD, Tatro JB, Duman RS. Life Sci. 1997; 61(1):1-9.
Review Peptide modulation of fever and inflammation within the brain. [Ann N Y Acad Sci. 1998]
Review Peptide modulation of fever and inflammation within the brain.
Catania A, Lipton JM. Ann N Y Acad Sci. 1998 Sep 29; 856:62-8.

See reviews... See all...

Cited by 8 PubMed Central articles

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PLoS One. 2011]
Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites.
King CM, Hentges ST. PLoS One. 2011; 6(10):e25864. Epub 2011 Oct 4.
Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat. [Physiol Behav. 2011]
Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat.
Davis JF, Choi DL, Shurdak JD, Krause EG, Fitzgerald MF, Lipton JW, Sakai RR, Benoit SC. Physiol Behav. 2011 Mar 28; 102(5):491-5. Epub 2010 Dec 21.
Review Hypothalamic mechanisms in cachexia. [Physiol Behav. 2010]
Review Hypothalamic mechanisms in cachexia.
Grossberg AJ, Scarlett JM, Marks DL. Physiol Behav. 2010 Jul 14; 100(5):478-89. Epub 2010 Mar 25.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamin...
The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine.
Neuroreport. 2001 Jul 20 ;12(10):2155-8.

PubMed
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected ...
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
Infect Immun. 2001 Aug ;69(8):5056-63.

PubMed
Synthesis of alpha-gal epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on human tumor c...
Synthesis of alpha-gal epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on human tumor cells by recombinant alpha1,3galactosyltransferase produced in Pichia pastoris.
Glycobiology. 2001 Jul ;11(7):577-86.

PubMed
Short- and long-term black tea consumption reverses endothelial dysfunction in p...
Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.
Circulation. 2001 Jul 10 ;104(2):151-6.

PubMed
Prevalence of antibodies to four herpesviruses among adults with glioma and cont...
Prevalence of antibodies to four herpesviruses among adults with glioma and controls.
Am J Epidemiol. 2001 Jul 15 ;154(2):161-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information