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Trends Endocrinol Metab. 2001 Aug;12(6):266-73.

Fatty acid transport proteins: a current view of a growing family.

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  • 1The Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142-1479, USA.

Erratum in

  • Trends Endocrinol Metab 2001 Sep;12(7):331.


Long-chain fatty acids (LCFAs) are a major caloric component of our diet and are key metabolites for energy generation and storage. Physiological uptake of LCFAs across cell membranes is a saturable and competable process occurring at low concentrations, indicative of protein-mediated transport. Fatty acid transport proteins are a family of transmembrane proteins that enhance LCFA uptake and are produced in all fatty acid-utilizing tissues. Here, we review our current understanding of the function, expression patterns and regulation and subcellular localization of this interesting family of proteins.

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