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Biochem Biophys Res Commun. 2001 Jul 13;285(2):561-4.

Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.

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  • 1Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Blå Stråket 5, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. nagaev@medic.gu.se

Abstract

Resistin is secreted by rodent fat cells and was recently postulated to be an important link between obesity and insulin resistance. We examined Resistin gene expression with real-time RT-PCR in human isolated fat cells, adipose tissue, and muscle from 42 individuals of varying degrees of overweight and who had normal insulin sensitivity or were insulin-resistant or Type 2 diabetic. Resistin was not expressed in human muscle nor was it expressed in most human isolated fat cells or intact biopsies. No difference was found between normal, insulin-resistant, or Type 2 diabetic samples. However, a very low but specific Resistin expression could be demonstrated in isolated fat cells and intact adipose tissue from some individuals (n = 3 and n = 4, respectively). There was no evidence for the expression of splice variants in the human samples. Thus, Resistin does not seem to be an important link to insulin resistance and Type 2 diabetes in human.

Copyright 2001 Academic Press.

PMID:
11444881
[PubMed - indexed for MEDLINE]
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