Source
Department of Human Biology, Maastricht University, Maastricht, The Netherlands. E.Kovacs@HB.UNIMAAS.NL
Abstract
OBJECTIVE:
Assessment of the effect of 2-week supplementation with (--)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety, fat oxidation, energy expenditure (EE) and body weight (BW) loss.
DESIGN:
Three intervention periods of 2 weeks separated by washout periods of 4 weeks. Double-blind, placebo-controlled, randomised and cross-over design.
SUBJECTS:
Eleven overweight male subjects (mean+/-s.d.; age, 47+/-16 y; body mass index, 27.4 +/- 8.2 kg/m(2)).
INTERVENTION:
Subjects consumed three self-selected meals and four iso-energetic (420 kJ) snacks daily with either no supplementation (PLA), 500 mg HCA (HCA) or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention ended with a 36 h stay in the respiration chamber.
RESULTS:
There was a significant BW loss during the 2 weeks of intervention (PLA, -1.0 +/- 0.4 kg, P<0.05; HCA, -1.5 +/- 0.5 kg, P<0.01; HCA+MCT, -1.3 +/- 0.2 kg, P<0.001), but this reduction was not different between treatments. 24 h EE (PLA, 11.8 +/- 0.2 MJ; HCA, 11.7 +/- 0.1 MJ; HCA+MCT, 11.5 +/- 0.1 MJ), 24 h RQ (0.85 +/- 0.00 in all treatments) and the area under the curve of the appetite-related parameters were not different between treatments.
CONCLUSION:
Two-week supplementation with HCA and HCA combined with MCT did not result in increased satiety, fat oxidation, 24 h EE or BW loss compared to PLA, in subjects losing BW.