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Trends Biochem Sci. 2001 Jul;26(7):407-9.

Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain.

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  • 1Molecular Biology and Bioinformatics Unit, Dept of Biology, University of Padua, Padova, Italy.


This article describes the discovery of a novel SNARE domain that might be involved in the regulation of membrane fusion. This domain is shared by a novel family of VAMPs called long VAMPs or longins. Members of this family are more conserved among eukaryotes than are classical VAMPs, possibly because of their underlying basic SNARE function.

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