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Cytogenet Cell Genet. 2001;92(3-4):300-3.

The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3.

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  • 1Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark.


Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8.

Copyright 2001 S. Karger AG, Basel.

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