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    Nat Rev Mol Cell Biol. 2001 Jul;2(7):493-503.

    Linking class-switch recombination with somatic hypermutation.

    Kinoshita K, Honjo T.

    Source

    Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-Ku, Kyoto 606-8501, Japan.

    Abstract

    The recent discovery of a molecular link between two apparently different genetic alteration events--class-switch recombination and somatic hypermutation--has led to the idea that the recognition and cleavage of target DNA in these two events might be mediated by similar or identical molecules to those involved in RNA editing. This could mean that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.

    PMID:
    11433363
    [PubMed - indexed for MEDLINE]

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