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Pediatrics. 2001 Jul;108(1):129-33.

Experience with the ketogenic diet in infants.

Author information

  • 1Epilepsy Center, Children's Memorial Hospital, Chicago, Illinois, USA. dnordli@childrensmemorial.org

Abstract

OBJECTIVE:

To evaluate the effectiveness, tolerability, and adverse effects of the ketogenic diet in infants with refractory epilepsy.

METHODS:

A retrospective review of 32 infants who had been treated with the ketogenic diet at a large metropolitan institution.

RESULTS:

Most infants (71%) were able to maintain strong ketosis. The overall effectiveness of the diet in infants was similar to that reported in the literature for older children; 19.4% became seizure-free, and an additional 35.5% had >50% reduction in seizure frequency. The diet was particularly effective for patients with infantile spasms/myoclonic seizures. There were concomitant reductions in antiepileptic medications. The majority of parents reported improvements in seizure frequency and in their child's behavior and function, particularly with respect to attention/alertness, activity level, and socialization. The diet generally was well-tolerated, and 96.4% maintained appropriate growth parameters. Adverse events, all reversible and occurring in one patient each, included renal stone, gastritis, ulcerative colitis, alteration of mentation, and hyperlipidemia.

CONCLUSION:

The ketogenic diet should be considered safe and effective treatment for infants with intractable seizures.

Comment in

  • Pitfalls of ketogenic diet in a neonate. [Pediatrics. 2002]
PMID:
11433065
[PubMed - indexed for MEDLINE]
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