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Nat Genet. 2001 Jul;28(3):220-1.

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

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  • 1Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Abstract

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.

PMID:
11431691
[PubMed - indexed for MEDLINE]
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