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BMJ. 2001 Jun 30;322(7302):1571.

Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women.

Author information

  • 1Department of Pediatrics, University of Oulu, Oulu, Fin-90220, Finland. terokontiokari@oulu.fi

Abstract

OBJECTIVE:

To determine whether recurrences of urinary tract infection can be prevented with cranberry-lingonberry juice or with Lactobacillus GG drink.

DESIGN:

Open, randomised controlled 12 month follow up trial.

SETTING:

Health centres for university students and staff of university hospital.

PARTICIPANTS:

150 women with urinary tract infection caused by Escherichia coli randomly allocated into three groups.

INTERVENTIONS:

50 ml of cranberry-lingonberry juice concentrate daily for six months or 100 ml of lactobacillus drink five days a week for one year, or no intervention.

MAIN OUTCOME MEASURE:

First recurrence of symptomatic urinary tract infection, defined as bacterial growth >/=10(5 )colony forming units/ml in a clean voided midstream urine specimen.

RESULTS:

The cumulative rate of first recurrence of urinary tract infection during the 12 month follow up differed significantly between the groups (P=0.048). At six months, eight (16%) women in the cranberry group, 19 (39%) in the lactobacillus group, and 18 (36%) in the control group had had at least one recurrence. This is a 20% reduction in absolute risk in the cranberry group compared with the control group (95% confidence interval 3% to 36%, P=0.023, number needed to treat=5, 95% confidence interval 3 to 34).

CONCLUSION:

Regular drinking of cranberry juice but not lactobacillus seems to reduce the recurrence of urinary tract infection.

Comment in

PMID:
11431298
[PubMed - indexed for MEDLINE]
PMCID:
PMC33514
Free PMC Article

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