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1: Intensive Care Med. 2001 May;27(5):803-11.Click here to read Links
Comment in:
Intensive Care Med. 2002 Aug;28(8):1185; author reply 1186.

Pathogenesis and treatment of renal dysfunction in rhabdomyolysis.

Holt SG, Moore KP.

Centre for Nephrology and Transplantation, Royal Free Hospital, Hampstead, London, UK. Stephen.Holt@rfh.nthames.nhs.uk

Rhabdomyolysis is a major cause of acute renal failure, and recent experimental data have provided a better understanding of the pathophysiology of the renal dysfunction. Renal failure is due to renal vasoconstriction, tubular damage caused by oxidant injury, and possibly tubular obstruction. Recent studies have provided greater insight into the rationale behind current therapy and potential treatment strategies. This review thus aims to summarise current understanding of the causes, pathogenesis and treatment of renal failure caused by rhabdomyolysis.

PMID: 11430535 [PubMed - indexed for MEDLINE]